Autophagy is one of the basic cellular biological pathways of body immunity

It can directly degrade invading microorganisms, and also regulate other core immune functions of multicellular organisms. include

(1) The autophagy effect of white blood cells captures the autophagy degradation of infectious microorganisms. The mechanism is the antimicrobial effect of SLR pattern recognition receptor (PRR), which captures macromolecular targets such as toxin protein aggregates, by relying on ATG factors Eliminate invading microbes in cells.

(2) The antimicrobial autophagy of mammalian cells is well integrated with other innate and adaptive immune regulatory systems, and its role is regulated by cytokines and receptors that regulate innate and adaptive immunity, such as NADPH oxidase and reactive oxygen species ( ROS) in Salmonella phagocytosis, it will activate both autophagy and ROS sterilization mechanisms.

(3) On the other hand, autophagy controls the inflammatory response by regulating the transmission of innate immune messages, mainly by removing the inducers of endogenous inflammatories and affecting the secretion of cellular mediators, such as reducing RLR and interferon (IFN). ), inhibit the activation of type I interleukin (IL-1α).

(4) Autophagy is also involved in the process of adaptive immunity, including antigen presentation, T cell balance, and the inflammatory response of Th17 cells.