The autophagy pathway or the unique function of autophagy proteins can regulate the operation of the immune system of organisms,
but the relationship between them is complicated.
Autophagy can induce the production of antibodies through the interaction with immune signal molecules,
help the release of cytokines, activate lymphocytes and immune cells,
increase inflammation and other immune functions,
and can also resist the invasion of foreign pathogens or perform tissue repair, etc. .
Autophagy can also negatively regulate the activation of immune cells to prevent excessive immune response from causing the body to become unable to load or cause diseases.
On the other hand, the signals released by immune cells can also induce or inhibit the occurrence of autophagy,
thereby helping other cells to eliminate old organelle proteins or eliminate pathogens.
On the whole, autophagy and immune and inflammatory reactions can be regulated and influenced each other. Therefore,
if one of them has problems, it may lead to diseases, such as inflammatory bowel disease Crohn’s disease, asthma, autoimmune disease Lupus erythematosus, ulcerative enteritis, etc.
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